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Understanding the mechanisms behind polynucleotide repair pathways is vital for developing therapies for genetic disorders caused by DNA damage.
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Polynucleotides also play a role in epigenetics—the study of heritable changes in gene expression that do not involve alterations to the underlying DNA sequence.
Understanding how environmental factors influence the stability and function of polynucleotides contributes to fields ranging from agriculture to conservation biology.
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Circular polynucleotides, such as plasmids, are commonly used in genetic engineering due to their ability to replicate independently within host cells.